ATCC® Number:VR-117™
Classification: Poxviridae, Orthopoxvirus
Agent: Vaccinia virus deposited as Vaccinia virus, Orthopoxvirus
Strain: CL
Original Source: Probably derived from New York City Department of Health strain of vaccinia
Depositors: F Fenner
Biosafety Level:2
Shipped: freeze-dried
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Host Organism : chicken embryo, chorioallantoic membrane inoculation chicken embryo; rabbit; monkey; chicken embryo fibroblasts
Incubation : Duration: 3 days
Effect : Yes, in vivo effects: causes pocks on chorioallantoic membrane
Comments : REFERENCE STRAIN: Fenner, F. et al., Virology 4:305,1957. This strain was used by J. Craigie in studies of antigenic composition and by T. M. Rivers and collaborators in studies of chemical composition of vaccinia virus. It is a dermal strain and produces rather small, opaque, white pocks on chorioallantoic membranes. It is non-pathogenic for mice (i. c.). The virus is very resistant and may contaminate the laboratory. Vaccination recommended for lab staff manipulating vaccinia, monkeypox, or cowpox viruses (CDC/NIH Biosafety in Microbiological and Biomedical Laboratories, 4th ed, 1999 - stock no. 017-040-00547-4).
References : 32714: Craigie J. . Br. J. Exp. Pathol. 13: 259, 1932. 32715: Parker RF, et al. Further studies of the infectious unit of Vaccinia. J. Exp. Med. 74: 263-281, 1941.