ATCC® Number:VR-2023™
Classification: Herpesviridae, Simplexvirus
Agent: Human herpesvirus 1 x 2 (recombinant) deposited as Herpes simplex virus 1 x 2 (Recombinant)
Strain: D3E2
Original Source: Crossing of parental strains of HSV-1 (KOStsE6) and HSV-2 (186tsB5)
Depositors: Institut Merieux
Biosafety Level:2
Shipped: freeze-dried
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Host Organism : HEp-2 cells (ATCCCCL-23); Vero cells (ATCCCCL-81)
Incubation : Max Temperature: 37.0°C Min Temperature: 35.0°C
Effect : Yes, in vitro effects: Cytopathic effects in tissue culture
Comments : Avirulent. Provides immunity to massive challenges of wild type strains of both HSV-1 and HSV-2. Low pathogenicity. NOTE: This material is cited in a U.S. and/or other Patent and may not be used to infringe the patent claims. Avirulent. Provides immunity to massive challenges of wild type strains of both HSV-1 and HSV-2. Low pathogenicity.
References : 3567: Roizman B, Lang MR. Vaccine and method of immunizing against herpes simplex virus (types 1 and 2). US Patent 4,554,159 dated Nov 19 1985 33227: Morse LS, et al. Anatomy of herpes simplex virus DNA. IX. Apparent exclusion of some parental DNA arrangements in the generation of intertypic (HSV-1 X HSV-2) recombinants. J. Virol. 24: 231-248, 1977. PubMed: 198577