ATCC® Number:VR-230™
Classification: Reoviridae, Orthoreovirus
Agent: Mammalian orthoreovirus 1 deposited as Reovirus type 1
Strain: Lang
Original Source: Rectal swab from healthy child, Ohio, 1953
Depositors: EH Lennette
Biosafety Level:2
Shipped: frozen
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Incubation : Atmosphere: air, 95%; carbon dioxide (CO2), 5% Duration: 2-6 days
Effect : Yes, in vitro effects: Cytopathic effects (granulated degeneration of cells and then destruction of entire cell sheet)
Comments : For passage cell cultures should be harvested after complete involvement of cell sheet. Culture fluid contains a group-specific CF antigen. REFERENCE STRAIN: Sabin, A.B., Science (Washington, DC) 130: 1387, 1959.
References : 32622: Ramos-Alvarez M, Sabin AB. Characteristics of poliomyelitis and other enteric viruses recovered in tissue culture from healthy American children. Proc. Soc. Exp. Biol. Med. 87: 655-661, 1954. PubMed: 13237336 32623: Ramos-Alvarez M, Sabin MB. Intestinal viral flora of healthy children demonstrable by monkey kidney tissue culture. Am. J. Public Health 46: 295-299, 1956. PubMed: 13292578