ATCC® Number:VR-1490™
Classification: Flaviviridae, Flavivirus
Agent: Dengue virus type 4
Strain: H241 (TC adapted)
Original Source: derived from existing strain (Derived at the ATCCfrom ATCCVR-217 (mouse passaged material, no longer available) by tissue culture passage in LLC-MK2 cells.)
Depositors: W Brandt, ATCC
Biosafety Level:2
Shipped: frozen
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Host Organism : Mus musculusHomo sapiensMacaca mulatta
Incubation : Duration: 4-10 days at 37C in tissue culture; 4-6 days in suckling mice
Effect : Yes, in vitro effects: Cytopathic effects in tissue culture (focal cell degeneration and inhibited cell growth) Yes, in vivo effects: death of suckling mice
Store at : -70C or lower
Comments : This virus appears to be one cause of Southeast Asian mosquito-borne hemorrhagic fever and has also been associated with classical Dengue fever. Many additional strains have been isolated from serum of human patients and Aedes aegypti and Aedes albopictus.