ATCC® Number:VR-766™
Classification: Nidovirales, Coronaviridae, Coronavirus,Group 2
Agent: Murine hepatitis virus
Strain: MHV-S Log #3239/17
Original Source: Isolated by i.c. and i.p. passage of viscera of 8 sick CD-1 mice in infant and suckling mice
Depositors: MJ Collins
Biosafety Level:2
Shipped: frozen
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Host Organism : NCTC clone 1469 cells (ATCCCCL-9.1) newborn mouse; NCTC clone 1469 cells (ATCCCCL-9.1)
Incubation : Temperature: 37.0°C Duration: 18-24 hours
Effect : Yes, in vitro effects: Cytopathic effects in tissue culture
Comments : Highly infectious in susceptible mouse colonies. Despite high mortality, the clinical signs in infected mice are often non-specific, with weakness or are suggestive of encephalitis with spasticity. Necropsy occasionally reveals small yellow or whitish spots on the liver.
References : 24563: Hartley JW, et al. Mouse hepatitis virus infection as a highly contagious, prevalent, enteric infection of mice. Proc. Soc. Exp. Biol. Med. 112: 161-165, 1963. PubMed: 13982823