ATCC® Number:VR-113™
Classification: Poxviridae, Leporipoxvirus, Myxoma virus
Agent: Rabbit fibroma virus deposited as Fibroma virus, Leporipoxvirus
Strain: Patuxent
Original Source: Cottontail rabbit tumor, Maryland, 1952
Depositors: JH Nakano
Biosafety Level:2
Shipped: frozen
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Host Organism : rabbit, i. d. inoculation; rabbit kidney cells rabbit (Oryctolagus); cottontail rabbit (Sylvilagus); rabbit kidney cells in tissue culture; rabbit testis cells in tissue culture
Incubation : Temperature: 35.5°C Duration: 4-7 days at 35.5C
Effect : Yes, in vitro effects: Cytopathic effects in tissue culture Yes, tumorigenicity: causes tumor at the site of inoculation
Comments : Inoculation of virus i.d. or i.t. results in viral proliferation and localized benign tumors. Generalization of infection does not occur, and tumors regress after a few weeks. The infected animals become resistant to myxoma virus. Inactivation of virus occurs rapidly at 4C.
References : 32673: Kilham L, Woke PA. Laboratory transmission of fibromas (Shope) in cottontail rabbits by means of fleas and mosquitoes. Proc. Soc. Exp. Biol. Med. 83: 296-301, 1953. PubMed: 13064250
