ATCC® Number:VR-553™
Classification: Togaviridae, Rubivirus
Agent: Rubella virus
Strain: To 336
Original Source: Throat swab from a 14-year-old female with German measles, Japan, 1967
Depositors: Takeda Chem. Ind., Ltd.
Biosafety Level:2
Shipped: frozen
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Host Organism : African green monkey kidney cells; BS-C-1 cells
Incubation : Duration: 7 days
Effect : No, in vitro effects: cytopathic effects in African green monkey kidney cells in tissue culture (infectivity was checked by interference to additional challenge with Echo 11 virus)
Comments : To-336 strain was identified as rubella by inhibition as well as neutralization using rabbit immune serum against prototype rubella virus, M-33 strain.
References : 3485: et al., Kono R. Highly attenuated rubella virus vaccine and production thereof. US Patent 3,655,872 dated Apr 11 1972 33641: Kono R, et al. Experimental vertical transmission of rubella virus in rabbits. Lancet 1: 343-347, 1969. PubMed: 4179354